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PMID: 38980576 | doi:10.1007/s10787-024-01499-8 Sikiric P et al

(6) Aaron Ciechanover and Patrik Brundin (2003) The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg Neuron, 2003 Oct 9, Volume 40 (Issue 2), Pages 427-46

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There are a certain amount of milligrams that a patch can hold. Collagen is another ingredient that cant be effectively absorbed via a patch, according to Davis-Urman